Symbol: Name: ID: |
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) GFS:6120 |
Gene name: | SNF8 |
Chromosome: | 17q21.32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | EAP30, VPS22, Dot3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1343161 | Rat Genome Database ID: | RGD:1310144 |
HGNC ID: | HGNC:17028 | RefSeq IDs: | NM_007241 |
Entrez Gene ID: | 11267 | Ensembl Gene ID: | ENSG00000159210 |
VEGA IDs: | UniProt ID: | Q96H20 | |
UCSC ID: | uc002ioj.2 | OMIM ID: | 610904 |
Pubmed: | PMID10419521 PMID 15329733 | ||
CCDS IDs: | CCDSCCDS11541.1 |
Vacuolar-sorting protein SNF8 is a protein that in humans is encoded by the SNF8 gene.
SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Products for SNF8 gene
Catalog | Product Name | Application | Company |
GFS:E06120 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06120 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06120 | SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae); Protien | Protien | n/a |