Symbol: Name: ID: |
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 GFS:5894 |
Gene name: | SMURF2 |
Chromosome: | 17q22-q23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1913563 | Rat Genome Database ID: | RGD:1310067 |
HGNC ID: | HGNC:16809 | RefSeq IDs: | NM_022739 |
Entrez Gene ID: | 64750 | Ensembl Gene ID: | ENSG00000108854 |
VEGA IDs: | UniProt ID: | Q9HAU4 | |
UCSC ID: | uc002jep.1 | OMIM ID: | 605532 |
Pubmed: | PMID11016919 | ||
CCDS IDs: | CCDSCCDS32707.1 |
E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the SMURF2 gene.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.
Products for SMURF2 gene
Catalog | Product Name | Application | Company |
GFS:E05894 | SMAD specific E3 ubiquitin protein ligase 2; ELISA kit | ELISA | n/a |
GFS:A05894 | SMAD specific E3 ubiquitin protein ligase 2; Anti | ANTIBODIES | n/a |
GFS:P05894 | SMAD specific E3 ubiquitin protein ligase 2; Protien | Protien | n/a |