| Symbol: Name: ID: |
SIVA1 SIVA1, apoptosis-inducing factor GFS:6639 |
| Gene name: | SIVA1 |
| Chromosome: | 14q32.33 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | SIVA, Siva-1, Siva-2, CD27BP |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1353606 | Rat Genome Database ID: | RGD:1561872 |
| HGNC ID: | HGNC:17712 | RefSeq IDs: | NM_006427 |
| Entrez Gene ID: | 10572 | Ensembl Gene ID: | ENSG00000184990 |
| VEGA IDs: | UniProt ID: | O15304 | |
| UCSC ID: | uc001yph.2 | OMIM ID: | 605567 |
| Pubmed: | PMID9177220 | ||
| CCDS IDs: | CCDSCCDS9992.1 CCDS CCDS9993.1 | ||
Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene.
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008].
Function: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Products for SIVA1 gene
| Catalog | Product Name | Application | Company |
| GFS:E06639 | SIVA1, apoptosis-inducing factor; ELISA kit | ELISA | n/a |
| GFS:A06639 | SIVA1, apoptosis-inducing factor; Anti | ANTIBODIES | n/a |
| GFS:P06639 | SIVA1, apoptosis-inducing factor; Protien | Protien | n/a |
