Symbol: Name: ID: |
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 GFS:755 |
Gene name: | SHC1 |
Chromosome: | 1q21 |
Previous Symbols: | SHC |
Previous Names: | SHC (Src homology 2 domain-containing) transforming protein 1 |
Aliases: | p66 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98296 | Rat Genome Database ID: | RGD:620446 |
HGNC ID: | HGNC:10840 | RefSeq IDs: | NM_001130040 |
Entrez Gene ID: | 6464 | Ensembl Gene ID: | ENSG00000160691 |
VEGA IDs: | OTTHUMG00000037295 | UniProt ID: | P29353 |
UCSC ID: | uc001ffw.2 | OMIM ID: | 600560 |
Pubmed: | PMID1623525 | ||
CCDS IDs: | CCDSCCDS1076.1 CCDS CCDS30881.1 CCDS CCDS44233.1 CCDS CCDS44234.1 |
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.SHC has been found to be important in the regulation of apoptosis and drug resistance in mammalian cells. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity).
Products for SHC1 gene
Catalog | Product Name | Application | Company |
GFS:E00755 | SHC (Src homology 2 domain containing) transforming protein 1; ELISA kit | ELISA | n/a |
GFS:A00755 | SHC (Src homology 2 domain containing) transforming protein 1; Anti | ANTIBODIES | n/a |
GFS:P00755 | SHC (Src homology 2 domain containing) transforming protein 1; Protien | Protien | n/a |