Symbol: Name: ID: |
SHANK2 SH3 and multiple ankyrin repeat domains 2 GFS:3657 |
Gene name: | SHANK2 |
Chromosome: | 11q13.2 |
Previous Symbols: | CORTBP1 |
Previous Names: | cortactin binding protein 1 |
Aliases: | CTTNBP1, ProSAP1, SHANK, SPANK-3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2671987 | Rat Genome Database ID: | RGD:628772 |
HGNC ID: | HGNC:14295 | RefSeq IDs: | NM_012309 |
Entrez Gene ID: | 22941 | Ensembl Gene ID: | ENSG00000162105 |
VEGA IDs: | OTTHUMG00000154615 | UniProt ID: | Q9UPX8 |
UCSC ID: | uc001oqc.2 | OMIM ID: | 603290 |
Pubmed: | PMID10506216 | ||
CCDS IDs: |
SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene.
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Products for SHANK2 gene
Catalog | Product Name | Application | Company |
GFS:E03657 | SH3 and multiple ankyrin repeat domains 2; ELISA kit | ELISA | n/a |
GFS:A03657 | SH3 and multiple ankyrin repeat domains 2; Anti | ANTIBODIES | n/a |
GFS:P03657 | SH3 and multiple ankyrin repeat domains 2; Protien | Protien | n/a |