Symbol: Name: ID: |
SATB1 SATB homeobox 1 GFS:480 |
Gene name: | SATB1 |
Chromosome: | 3p24.3 |
Previous Symbols: | |
Previous Names: | special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA's) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105084 | Rat Genome Database ID: | RGD:1305561 |
HGNC ID: | HGNC:10541 | RefSeq IDs: | NM_001131010 |
Entrez Gene ID: | 6304 | Ensembl Gene ID: | ENSG00000182568 |
VEGA IDs: | OTTHUMG00000129890 | UniProt ID: | Q01826 |
UCSC ID: | uc003cbj.2 | OMIM ID: | 602075 |
Pubmed: | PMID1505028 | ||
CCDS IDs: | CCDSCCDS2631.1 |
This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis
Products for SATB1 gene
Catalog | Product Name | Application | Company |
GFS:E00480 | SATB homeobox 1; ELISA kit | ELISA | n/a |
GFS:A00480 | SATB homeobox 1; Anti | ANTIBODIES | n/a |
GFS:P00480 | SATB homeobox 1; Protien | Protien | n/a |