Symbol: Name: ID: |
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 GFS:224 |
Gene name: | ROCK1 |
Chromosome: | 18q11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | p160ROCK |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107927 | Rat Genome Database ID: | RGD:620424 |
HGNC ID: | HGNC:10251 | RefSeq IDs: | NM_005406 |
Entrez Gene ID: | 6093 | Ensembl Gene ID: | ENSG00000067900 |
VEGA IDs: | OTTHUMG00000131723 | UniProt ID: | Q13464 |
UCSC ID: | uc002kke.2 | OMIM ID: | 601702 |
Pubmed: | PMID8617235 | ||
CCDS IDs: | CCDSCCDS11870.2 |
Rho-associated, coiled-coil containing protein kinase 1 encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. (provided by RefSeq)
Products for ROCK1 gene
Catalog | Product Name | Application | Company |
GFS:E00224 | Rho-associated, coiled-coil containing protein kinase 1; ELISA kit | ELISA | n/a |
GFS:A00224 | Rho-associated, coiled-coil containing protein kinase 1; Anti | ANTIBODIES | n/a |
GFS:P00224 | Rho-associated, coiled-coil containing protein kinase 1; Protien | Protien | n/a |