Symbol: Name: ID: |
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 GFS:6575 |
Gene name: | RASSF5 |
Chromosome: | 1q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | Maxp1, NORE1, RAPL |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1926375 | Rat Genome Database ID: | RGD:621694 |
HGNC ID: | HGNC:17609 | RefSeq IDs: | NM_182663 |
Entrez Gene ID: | 83593 | Ensembl Gene ID: | ENSG00000136653 |
VEGA IDs: | OTTHUMG00000036343 | UniProt ID: | Q8WWW0 |
UCSC ID: | uc001hed.2 | OMIM ID: | 607020 |
Pubmed: | PMID11978988 PMID 11965544 | ||
CCDS IDs: | CCDSCCDS1463.1 CCDS CCDS1464.1 CCDS CCDS30998.1 |
Ras association domain-containing protein 5 is a protein that in humans is encoded by the RASSF5 or F5 gene.
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.
Products for RASSF5 gene
Catalog | Product Name | Application | Company |
GFS:E06575 | Ras association (RalGDS/AF-6) domain family member 5; ELISA kit | ELISA | n/a |
GFS:A06575 | Ras association (RalGDS/AF-6) domain family member 5; Anti | ANTIBODIES | n/a |
GFS:P06575 | Ras association (RalGDS/AF-6) domain family member 5; Protien | Protien | n/a |