Symbol: Name: ID: |
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 GFS:5001 |
Gene name: | RBCK1 |
Chromosome: | 20p13 |
Previous Symbols: | C20orf18 |
Previous Names: | chromosome 20 open reading frame 18 |
Aliases: | RBCK2, XAP4, RNF54, ZRANB4, UBCE7IP3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344372 | Rat Genome Database ID: | RGD:708404 |
HGNC ID: | HGNC:15864 | RefSeq IDs: | NM_006462 |
Entrez Gene ID: | 10616 | Ensembl Gene ID: | ENSG00000125826 |
VEGA IDs: | OTTHUMG00000031634 | UniProt ID: | Q9BYM8 |
UCSC ID: | uc002wdp.3 | OMIM ID: | 610924 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS12998.1 CCDS CCDS13000.2 |
RanBP-type and C3HC4-type zinc finger-containing protein 1 is a protein that in humans is encoded by the RBCK1 gene.
The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Acts as an E3 ubiquitin-protein ligase, or as part of an E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteoasome. Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. LUBAC conjugates linear polyubiquitin to IKBKG at 'Lys-285' and 'Lys-309' and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.
Products for RBCK1 gene
Catalog | Product Name | Application | Company |
GFS:E05001 | RanBP-type and C3HC4-type zinc finger containing 1; ELISA kit | ELISA | n/a |
GFS:A05001 | RanBP-type and C3HC4-type zinc finger containing 1; Anti | ANTIBODIES | n/a |
GFS:P05001 | RanBP-type and C3HC4-type zinc finger containing 1; Protien | Protien | n/a |