Symbol: Name: ID: |
REV1 REV1 homolog (S. cerevisiae) GFS:3487 |
Gene name: | REV1 |
Chromosome: | 2q11.1-q11.2 |
Previous Symbols: | REV1L |
Previous Names: | REV1 (yeast homolog)- like, "REV1-like (yeast)" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929074 | Rat Genome Database ID: | RGD:1306715 |
HGNC ID: | HGNC:14060 | RefSeq IDs: | NM_001037872 |
Entrez Gene ID: | 51455 | Ensembl Gene ID: | ENSG00000135945 |
VEGA IDs: | OTTHUMG00000130636 | UniProt ID: | Q9UBZ9 |
UCSC ID: | uc002tad.2 | OMIM ID: | 606134 |
Pubmed: | PMID10536157 | ||
CCDS IDs: | CCDSCCDS2045.1 CCDS CCDS42722.1 |
DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008].
Function: Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
Products for REV1 gene
Catalog | Product Name | Application | Company |
GFS:E03487 | REV1 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A03487 | REV1 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P03487 | REV1 homolog (S. cerevisiae); Protien | Protien | n/a |