Symbol: Name: ID: |
REC8 REC8 homolog (yeast) GFS:5965 |
Gene name: | REC8 |
Chromosome: | 14q11.2-q12 |
Previous Symbols: | REC8L1 |
Previous Names: | REC8-like 1 (yeast) |
Aliases: | Rec8p |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929645 | Rat Genome Database ID: | RGD:1309376 |
HGNC ID: | HGNC:16879 | RefSeq IDs: | NM_005132 |
Entrez Gene ID: | 9985 | Ensembl Gene ID: | ENSG00000100918 |
VEGA IDs: | UniProt ID: | O95072 | |
UCSC ID: | uc001wms.2 | OMIM ID: | 608193 |
Pubmed: | PMID10207075 PMID 15935783 PMID 12759374 | ||
CCDS IDs: | CCDSCCDS41932.1 |
Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene.
This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity).
Products for REC8 gene
Catalog | Product Name | Application | Company |
GFS:E05965 | REC8 homolog (yeast); ELISA kit | ELISA | n/a |
GFS:A05965 | REC8 homolog (yeast); Anti | ANTIBODIES | n/a |
GFS:P05965 | REC8 homolog (yeast); Protien | Protien | n/a |