Symbol: Name: ID: |
RSPO4 R-spondin family, member 4 GFS:5301 |
Gene name: | RSPO4 |
Chromosome: | 20p13 |
Previous Symbols: | C20orf182 |
Previous Names: | chromosome 20 open reading frame 182 |
Aliases: | dJ824F16.3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1924467 | Rat Genome Database ID: | RGD:1563415 |
HGNC ID: | HGNC:16175 | RefSeq IDs: | NM_001029871 |
Entrez Gene ID: | 343637 | Ensembl Gene ID: | ENSG00000101282 |
VEGA IDs: | OTTHUMG00000031651 | UniProt ID: | Q2I0M5 |
UCSC ID: | uc002wej.2 | OMIM ID: | 610573 |
Pubmed: | PMID15469841 | ||
CCDS IDs: | CCDSCCDS42845.1 CCDS CCDS42846.1 |
This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009].
Function: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors (By similarity).
Products for RSPO4 gene
Catalog | Product Name | Application | Company |
GFS:E05301 | R-spondin family, member 4; ELISA kit | ELISA | n/a |
GFS:A05301 | R-spondin family, member 4; Anti | ANTIBODIES | n/a |
GFS:P05301 | R-spondin family, member 4; Protien | Protien | n/a |