Symbol: Name: ID: |
PARK7 Parkinson disease (autosomal recessive, early onset) 7 GFS:5484 |
Gene name: | PARK7 |
Chromosome: | 1p36.23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | DJ-1, DJ1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2135637 | Rat Genome Database ID: | RGD:621808 |
HGNC ID: | HGNC:16369 | RefSeq IDs: | NM_001123377 |
Entrez Gene ID: | 11315 | Ensembl Gene ID: | ENSG00000116288 |
VEGA IDs: | OTTHUMG00000001210 | UniProt ID: | Q99497 |
UCSC ID: | uc001aox.3 | OMIM ID: | 602533 |
Pubmed: | PMID11462174 PMID 9070310 | ||
CCDS IDs: | CCDSCCDS93.1 |
Parkinson disease (autosomal recessive, early onset) 7, also known as PARK7, is a protein which in humans is encoded by the PARK7 gene.
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Function: Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Stabilizes NFE2L2 by preventing its association with KEAP1 and its subsequent ubiquitination. Binds to OTUD7B and inhibits its deubiquitinating activity. Enhances RELA nuclear translocation. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone.
Products for PARK7 gene
Catalog | Product Name | Application | Company |
GFS:E05484 | Parkinson disease (autosomal recessive, early onset) 7; ELISA kit | ELISA | n/a |
GFS:A05484 | Parkinson disease (autosomal recessive, early onset) 7; Anti | ANTIBODIES | n/a |
GFS:P05484 | Parkinson disease (autosomal recessive, early onset) 7; Protien | Protien | n/a |