Symbol: Name: ID: |
PRPF8 PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae) GFS:6418 |
Gene name: | PRPF8 |
Chromosome: | 17p13.3 |
Previous Symbols: | RP13 |
Previous Names: | PRP8 pre-mRNA processing factor 8 homolog (yeast) |
Aliases: | PRPC8, Prp8 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2179381 | Rat Genome Database ID: | RGD:1305467 |
HGNC ID: | HGNC:17340 | RefSeq IDs: | NM_006445 |
Entrez Gene ID: | 10594 | Ensembl Gene ID: | ENSG00000174231 |
VEGA IDs: | OTTHUMG00000090553 | UniProt ID: | Q6P2Q9 |
UCSC ID: | uc002fte.2 | OMIM ID: | 607300 |
Pubmed: | PMID11468273 PMID 10411133 | ||
CCDS IDs: | CCDSCCDS11010.1 |
Pre-mRNA-processing-splicing factor 8 is a protein that in humans is encoded by the PRPF8 gene.
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
Products for PRPF8 gene
Catalog | Product Name | Application | Company |
GFS:E06418 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06418 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06418 | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Protien | Protien | n/a |