Symbol: Name: ID: |
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 GFS:2768 |
Gene name: | PATZ1 |
Chromosome: | 22q12.2 |
Previous Symbols: | ZNF278 |
Previous Names: | zinc finger protein 278 |
Aliases: | MAZR, dJ400N23, ZBTB19, ZSG, RIAZ, PATZ |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1891832 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13071 | RefSeq IDs: | NM_014323 |
Entrez Gene ID: | 23598 | Ensembl Gene ID: | ENSG00000100105 |
VEGA IDs: | OTTHUMG00000151254 | UniProt ID: | Q9HBE1 |
UCSC ID: | uc003akq.2 | OMIM ID: | 605165 |
Pubmed: | PMID10591208 PMID 18241078 PMID 18401526 | ||
CCDS IDs: | CCDSCCDS13894.1 CCDS CCDS13895.1 CCDS CCDS13896.1 CCDS CCDS46691.1 |
POZ-, AT hook-, and zinc finger-containing protein 1 is a protein that in humans is encoded by the PATZ1 gene.
The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq].
Products for PATZ1 gene
Catalog | Product Name | Application | Company |
GFS:E02768 | POZ (BTB) and AT hook containing zinc finger 1; ELISA kit | ELISA | n/a |
GFS:A02768 | POZ (BTB) and AT hook containing zinc finger 1; Anti | ANTIBODIES | n/a |
GFS:P02768 | POZ (BTB) and AT hook containing zinc finger 1; Protien | Protien | n/a |