Symbol: Name: ID: |
NDFIP1 Nedd4 family interacting protein 1 GFS:6569 |
Gene name: | NDFIP1 |
Chromosome: | 5q31.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | N4WBP5, MGC10924 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1929601 | Rat Genome Database ID: | RGD:1310053 |
HGNC ID: | HGNC:17592 | RefSeq IDs: | NM_030571 |
Entrez Gene ID: | 80762 | Ensembl Gene ID: | ENSG00000131507 |
VEGA IDs: | OTTHUMG00000129659 | UniProt ID: | Q9BT67 |
UCSC ID: | uc003lmi.3 | OMIM ID: | 612050 |
Pubmed: | PMID11042109 PMID 11748237 | ||
CCDS IDs: | CCDSCCDS4273.1 |
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate.
Products for NDFIP1 gene
Catalog | Product Name | Application | Company |
GFS:E06569 | Nedd4 family interacting protein 1; ELISA kit | ELISA | n/a |
GFS:A06569 | Nedd4 family interacting protein 1; Anti | ANTIBODIES | n/a |
GFS:P06569 | Nedd4 family interacting protein 1; Protien | Protien | n/a |