Symbol: Name: ID: |
NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae) GFS:3916 |
Gene name: | NUF2 |
Chromosome: | 1q23.3 |
Previous Symbols: | CDCA1 |
Previous Names: | cell division cycle associated 1 |
Aliases: | NUF2R, CT106 |
Name Aliases: | cancer/testis antigen 106 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914227 | Rat Genome Database ID: | RGD:1307952 |
HGNC ID: | HGNC:14621 | RefSeq IDs: | NM_031423 |
Entrez Gene ID: | 83540 | Ensembl Gene ID: | ENSG00000143228 |
VEGA IDs: | OTTHUMG00000034275 | UniProt ID: | Q9BZD4 |
UCSC ID: | uc001gcr.1 | OMIM ID: | 611772 |
Pubmed: | PMID11266451 PMID 11685532 | ||
CCDS IDs: | CCDSCCDS1245.1 |
Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.
This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008].
Function: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore.
Products for NUF2 gene
Catalog | Product Name | Application | Company |
GFS:E03916 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A03916 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P03916 | NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae); Protien | Protien | n/a |