Symbol: Name: ID: |
NLRP1 NLR family, pyrin domain containing 1 GFS:3720 |
Gene name: | NLRP1 |
Chromosome: | 17p13 |
Previous Symbols: | NALP1 |
Previous Names: | NACHT, leucine rich repeat and PYD (pyrin domain) containing 1 |
Aliases: | KIAA0926, DKFZp586O1822, CARD7, NAC, CLR17.1, DEFCAP |
Name Aliases: | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2684861 | Rat Genome Database ID: | RGD:1310963 |
HGNC ID: | HGNC:14374 | RefSeq IDs: | NM_001033053 |
Entrez Gene ID: | 22861 | Ensembl Gene ID: | ENSG00000091592 |
VEGA IDs: | UniProt ID: | Q9C000 | |
UCSC ID: | uc002gci.2 | OMIM ID: | 606636 |
Pubmed: | PMID8781126 PMID 12563287 | ||
CCDS IDs: | CCDSCCDS32537.1 CCDS CCDS42244.1 CCDS CCDS42245.1 CCDS CCDS42246.1 |
NACHT, LRR and PYD domains-containing protein 1 is a protein that in humans is encoded by the NLRP1 gene.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008].
Function: Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.
Products for NLRP1 gene
Catalog | Product Name | Application | Company |
GFS:E03720 | NLR family, pyrin domain containing 1; ELISA kit | ELISA | n/a |
GFS:A03720 | NLR family, pyrin domain containing 1; Anti | ANTIBODIES | n/a |
GFS:P03720 | NLR family, pyrin domain containing 1; Protien | Protien | n/a |