| Symbol: Name: ID: |
NLRC4 NLR family, CARD domain containing 4 GFS:5528 |
| Gene name: | NLRC4 |
| Chromosome: | 2p22-p21 |
| Previous Symbols: | CARD12 |
| Previous Names: | caspase recruitment domain family, member 12 |
| Aliases: | CLAN1, ipaf, CLANA, CLANB, CLANC, CLAND, CLR2.1, CLAN |
| Name Aliases: | nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4, |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:3036243 | Rat Genome Database ID: | RGD:1309831 |
| HGNC ID: | HGNC:16412 | RefSeq IDs: | NM_001199138 |
| Entrez Gene ID: | 58484 | Ensembl Gene ID: | ENSG00000091106 |
| VEGA IDs: | OTTHUMG00000152107 | UniProt ID: | Q9NPP4 |
| UCSC ID: | uc002roj.1 | OMIM ID: | 606831 |
| Pubmed: | PMID11374873 | ||
| CCDS IDs: | CCDSCCDS33174.1 | ||
NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene.
In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM, Mar 2008].
Function: Plays a role in the promotion of apoptosis.
Products for NLRC4 gene
| Catalog | Product Name | Application | Company |
| GFS:E05528 | NLR family, CARD domain containing 4; ELISA kit | ELISA | n/a |
| GFS:A05528 | NLR family, CARD domain containing 4; Anti | ANTIBODIES | n/a |
| GFS:P05528 | NLR family, CARD domain containing 4; Protien | Protien | n/a |
