Symbol: Name: ID: |
NKX2-1 NK2 homeobox 1 GFS:1640 |
Gene name: | NKX2-1 |
Chromosome: | 14q13.3 |
Previous Symbols: | NKX2A, BCH, TITF1 |
Previous Names: | benign chorea, "thyroid transcription factor 1" |
Aliases: | TTF-1, TTF1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108067 | Rat Genome Database ID: | RGD:3866 |
HGNC ID: | HGNC:11825 | RefSeq IDs: | NM_001079668 |
Entrez Gene ID: | 7080 | Ensembl Gene ID: | ENSG00000136352 |
VEGA IDs: | OTTHUMG00000140225 | UniProt ID: | P43699 |
UCSC ID: | uc001wtu.2 | OMIM ID: | 600635 |
Pubmed: | PMID1976511 | ||
CCDS IDs: | CCDSCCDS9659.1 CCDS CCDS41945.1 |
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TFF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription. [provided by RefSeq].
Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis.
Products for NKX2-1 gene
Catalog | Product Name | Application | Company |
GFS:E01640 | NK2 homeobox 1; ELISA kit | ELISA | n/a |
GFS:A01640 | NK2 homeobox 1; Anti | ANTIBODIES | n/a |
GFS:P01640 | NK2 homeobox 1; Protien | Protien | n/a |