Symbol: Name: ID: |
NCKIPSD NCK interacting protein with SH3 domain GFS:4694 |
Gene name: | NCKIPSD |
Chromosome: | 3p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | AF3P21, SPIN90, ORF1, WISH, WASLBP, DIP1 |
Name Aliases: | dia interacting protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1931834 | Rat Genome Database ID: | RGD:1311323 |
HGNC ID: | HGNC:15486 | RefSeq IDs: | NM_016453 |
Entrez Gene ID: | 51517 | Ensembl Gene ID: | ENSG00000213672 |
VEGA IDs: | OTTHUMG00000133542 | UniProt ID: | Q9NZQ3 |
UCSC ID: | uc003cun.2 | OMIM ID: | 606671 |
Pubmed: | PMID10648423 PMID 10619843 | ||
CCDS IDs: | CCDSCCDS2776.1 CCDS CCDS46827.1 |
NCK-interacting protein with SH3 domain is a protein that in humans is encoded by the NCKIPSD gene.
The protein encoded by this gene is localized exclusively in the cell nucleus. It plays a role in signal transduction, and may function in the maintenance of sarcomeres and in the assembly of myofibrils into sarcomeres. It also plays an important role in stress fiber formation. The gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion.
Products for NCKIPSD gene
Catalog | Product Name | Application | Company |
GFS:E04694 | NCK interacting protein with SH3 domain; ELISA kit | ELISA | n/a |
GFS:A04694 | NCK interacting protein with SH3 domain; Anti | ANTIBODIES | n/a |
GFS:P04694 | NCK interacting protein with SH3 domain; Protien | Protien | n/a |