Symbol: Name: ID: |
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 GFS:6281 |
Gene name: | NDUFA13 |
Chromosome: | 19p13.11 |
Previous Symbols: | |
Previous Names: | |
Aliases: | CGI-39, CDA016, GRIM-19, GRIM19, B16.6 |
Name Aliases: | complex I B16.6 subunit |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914434 | Rat Genome Database ID: | RGD:1565358 |
HGNC ID: | HGNC:17194 | RefSeq IDs: | NM_015965 |
Entrez Gene ID: | 51079 | Ensembl Gene ID: | ENSG00000186010 |
VEGA IDs: | OTTHUMG00000162211 | UniProt ID: | Q9P0J0 |
UCSC ID: | OMIM ID: | 609435 | |
Pubmed: | PMID12837546 PMID 10924506 PMID 15367666 | ||
CCDS IDs: | CCDSCCDS12404.1 |
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 is an enzyme that in humans is encoded by the NDUFA13 gene.
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. (provided byRefSeq)
Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Products for NDUFA13 gene
Catalog | Product Name | Application | Company |
GFS:E06281 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; ELISA kit | ELISA | n/a |
GFS:A06281 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; Anti | ANTIBODIES | n/a |
GFS:P06281 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13; Protien | Protien | n/a |