Symbol: Name: ID: |
NECAB3 N-terminal EF-hand calcium binding protein 3 GFS:4988 |
Gene name: | NECAB3 |
Chromosome: | 20q11.21 |
Previous Symbols: | SYTIP2, APBA2BP |
Previous Names: | amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein |
Aliases: | XB51, dJ63M2.4, NIP1, dJ63M2.5, EFCBP3 |
Name Aliases: | EF-hand calcium binding protein 3 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1861721 | Rat Genome Database ID: | RGD:1310124 |
HGNC ID: | HGNC:15851 | RefSeq IDs: | NM_031231 |
Entrez Gene ID: | 63941 | Ensembl Gene ID: | ENSG00000125967 |
VEGA IDs: | OTTHUMG00000032264 | UniProt ID: | Q96P71 |
UCSC ID: | uc002wzm.3 | OMIM ID: | 612478 |
Pubmed: | PMID10833507 | ||
CCDS IDs: | CCDSCCDS42866.1 CCDS CCDS42867.1 |
N-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.
The protein encoded by this gene interacts with the amino-terminal domain of the neuron-specific X11-like protein (X11L), inhibits the association of X11L with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by X11L. This protein, together with X11L, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. The protein is phosphorylated by NIMA-related expressed kinase 2, and localizes to the Golgi apparatus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Function: Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta-amyloid.
Products for NECAB3 gene
Catalog | Product Name | Application | Company |
GFS:E04988 | N-terminal EF-hand calcium binding protein 3; ELISA kit | ELISA | n/a |
GFS:A04988 | N-terminal EF-hand calcium binding protein 3; Anti | ANTIBODIES | n/a |
GFS:P04988 | N-terminal EF-hand calcium binding protein 3; Protien | Protien | n/a |