Symbol: Name: ID: |
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 GFS:7680 |
Gene name: | ASAH2 |
Chromosome: | 10q11.23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1859310 | Rat Genome Database ID: | RGD:69410 |
HGNC ID: | HGNC:18860 | RefSeq IDs: | NM_001143974 |
Entrez Gene ID: | 56624 | Ensembl Gene ID: | ENSG00000188611 |
VEGA IDs: | OTTHUMG00000018223 | UniProt ID: | Q9NR71 |
UCSC ID: | uc001jjd.2 | OMIM ID: | 611202 |
Pubmed: | PMID10781606 | ||
CCDS IDs: | CCDSCCDS7239.2 CCDS CCDS44398.1 |
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene.
Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001 [PubMed 11328816]).[supplied by OMIM, Mar 2008].
Function: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.
Products for ASAH2 gene
Catalog | Product Name | Application | Company |
GFS:E07680 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; ELISA kit | ELISA | n/a |
GFS:A07680 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Anti | ANTIBODIES | n/a |
GFS:P07680 | N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2; Protien | Protien | n/a |