Symbol: Name: ID: |
MOBKL1B MOB1, Mps One Binder kinase activator-like 1B (yeast) GFS:5145 |
Gene name: | MOBKL1B |
Chromosome: | 2p13.1 |
Previous Symbols: | C2orf6, MOBK1B |
Previous Names: | chromosome 2 open reading frame 6 |
Aliases: | FLJ10788, MOB1, FLJ11595, Mob4B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2442631 | Rat Genome Database ID: | RGD:1307014 |
HGNC ID: | HGNC:16015 | RefSeq IDs: | NM_018221 |
Entrez Gene ID: | 55233 | Ensembl Gene ID: | ENSG00000114978 |
VEGA IDs: | OTTHUMG00000152833 | UniProt ID: | Q9H8S9 |
UCSC ID: | uc002skh.3 | OMIM ID: | 609281 |
Pubmed: | PMID11319234 | ||
CCDS IDs: | CCDSCCDS46340.1 |
Mps one binder kinase activator-like 1B is an enzyme that in humans is encoded by the MOBKL1B gene.
Function: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
Products for MOBKL1B gene
Catalog | Product Name | Application | Company |
GFS:E05145 | MOB1, Mps One Binder kinase activator-like 1B (yeast); ELISA kit | ELISA | n/a |
GFS:A05145 | MOB1, Mps One Binder kinase activator-like 1B (yeast); Anti | ANTIBODIES | n/a |
GFS:P05145 | MOB1, Mps One Binder kinase activator-like 1B (yeast); Protien | Protien | n/a |