Symbol: Name: ID: |
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae) GFS:6109 |
Gene name: | LSM6 |
Chromosome: | 4q31.21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | YDR378C |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1925901 | Rat Genome Database ID: | RGD:1561937 |
HGNC ID: | HGNC:17017 | RefSeq IDs: | NM_007080 |
Entrez Gene ID: | 11157 | Ensembl Gene ID: | ENSG00000164167 |
VEGA IDs: | UniProt ID: | P62312 | |
UCSC ID: | uc003ikq.3 | OMIM ID: | 607286 |
Pubmed: | PMID10369684 PMID 10523320 | ||
CCDS IDs: | CCDSCCDS3767.1 |
U6 snRNA-associated Sm-like protein LSm6 is a protein that in humans is encoded by the LSM6 gene.
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004].
Function: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).
Products for LSM6 gene
Catalog | Product Name | Application | Company |
GFS:E06109 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06109 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06109 | LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae); Protien | Protien | n/a |