Symbol: Name: ID: |
LDB3 LIM domain binding 3 GFS:4873 |
Gene name: | LDB3 |
Chromosome: | 10q22.3-q23.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | PDLIM6, KIAA0613, ZASP |
Name Aliases: | cypher, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344412 | Rat Genome Database ID: | RGD:1564875 |
HGNC ID: | HGNC:15710 | RefSeq IDs: | NM_001080114 |
Entrez Gene ID: | 11155 | Ensembl Gene ID: | ENSG00000122367 |
VEGA IDs: | OTTHUMG00000018655 | UniProt ID: | O75112 |
UCSC ID: | uc001kdv.2 | OMIM ID: | 605906 |
Pubmed: | PMID10427098 | ||
CCDS IDs: | CCDSCCDS7377.1 CCDS CCDS41544.1 CCDS CCDS41545.1 CCDS CCDS44450.1 |
LIM domain binding 3, also known as LDB3 or ZASP, is a protein which in humans is encoded by the LDB3 gene.
This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010].
Function: May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton.
Products for LDB3 gene
Catalog | Product Name | Application | Company |
GFS:E04873 | LIM domain binding 3; ELISA kit | ELISA | n/a |
GFS:A04873 | LIM domain binding 3; Anti | ANTIBODIES | n/a |
GFS:P04873 | LIM domain binding 3; Protien | Protien | n/a |