Symbol: Name: ID: |
TDH L-threonine dehydrogenase GFS:4746 |
Gene name: | TDH |
Chromosome: | 8p23.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | FLJ25033, SDR14E1P |
Name Aliases: | short chain dehydrogenase/reductase family 14E, member 1 (pseudogene) |
Locus Type: | pseudogene |
Mouse Genome Database ID: | MGI:1926231 | Rat Genome Database ID: | RGD:1310214 |
HGNC ID: | HGNC:15547 | RefSeq IDs: | NR_001578 |
Entrez Gene ID: | 157739 | Ensembl Gene ID: | ENSG00000154316 |
VEGA IDs: | UniProt ID: | Q8IZJ6 | |
UCSC ID: | uc003wtq.1 | OMIM ID: | |
Pubmed: | PMID11896452 PMID 12361482 PMID 19027726 | ||
CCDS IDs: |
This gene appears to be an evolving pseudogene of L-threonine 3-dehydrogenase (TDH). In both prokaryotes and eukaryotes, TDH catalyzes the first of two steps in one of two L-threonine degradation pathways. However, in human, the single gene with sequence similarity to TDH is not capable of encoding a functional TDH protein; the predicted protein lacks most of the C-terminus and parts of the NAD+ binding motif when compared to other species' TDH proteins. This suggests that the human gene is therefore a pseudogene. Transcripts of this gene are found in all tissues and alternatively spliced transcripts have been described. It is not known if these transcripts are translated, or if the possible protein product provides any functional role. [provided by RefSeq, Jul 2008].
Products for TDH gene
Catalog | Product Name | Application | Company |
GFS:E04746 | L-threonine dehydrogenase; ELISA kit | ELISA | n/a |
GFS:A04746 | L-threonine dehydrogenase; Anti | ANTIBODIES | n/a |
GFS:P04746 | L-threonine dehydrogenase; Protien | Protien | n/a |