Symbol: Name: ID: |
KRIT1 KRIT1, ankyrin repeat containing GFS:4887 |
Gene name: | KRIT1 |
Chromosome: | 7q21.2 |
Previous Symbols: | CCM1 |
Previous Names: | cerebral cavernous malformations 1 |
Aliases: | CAM |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1930618 | Rat Genome Database ID: | RGD:1305929 |
HGNC ID: | HGNC:1573 | RefSeq IDs: | NM_001013406 |
Entrez Gene ID: | 889 | Ensembl Gene ID: | ENSG00000001631 |
VEGA IDs: | OTTHUMG00000131187 | UniProt ID: | O00522 |
UCSC ID: | uc003ulu.1 | OMIM ID: | 604214 |
Pubmed: | PMID7604043 PMID 11342228 | ||
CCDS IDs: | CCDSCCDS5624.1 CCDS CCDS34679.1 |
Krev interaction trapped protein 1 is a protein that in humans is encoded by the KRIT1 gene.
This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009].
Products for KRIT1 gene
Catalog | Product Name | Application | Company |
GFS:E04887 | KRIT1, ankyrin repeat containing; ELISA kit | ELISA | n/a |
GFS:A04887 | KRIT1, ankyrin repeat containing; Anti | ANTIBODIES | n/a |
GFS:P04887 | KRIT1, ankyrin repeat containing; Protien | Protien | n/a |