Symbol: Name: ID: |
GAB2 GRB2-associated binding protein 2 GFS:3787 |
Gene name: | GAB2 |
Chromosome: | 11q13.4-q13.5 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KIAA0571 |
Name Aliases: | Grb2-associated binder 2 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1333854 | Rat Genome Database ID: | RGD:621367 |
HGNC ID: | HGNC:14458 | RefSeq IDs: | NM_012296 |
Entrez Gene ID: | 9846 | Ensembl Gene ID: | ENSG00000033327 |
VEGA IDs: | UniProt ID: | Q9UQC2 | |
UCSC ID: | uc001ozh.2 | OMIM ID: | 606203 |
Pubmed: | PMID10391903 PMID 10068651 | ||
CCDS IDs: | CCDSCCDS8259.1 CCDS CCDS8260.1 |
GRB2-associated-binding protein 2 is a protein that in humans is encoded by the GAB2 gene.
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
Function: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.
Products for GAB2 gene
Catalog | Product Name | Application | Company |
GFS:E03787 | GRB2-associated binding protein 2; ELISA kit | ELISA | n/a |
GFS:A03787 | GRB2-associated binding protein 2; Anti | ANTIBODIES | n/a |
GFS:P03787 | GRB2-associated binding protein 2; Protien | Protien | n/a |