| Symbol: Name: ID: |
FAIM3 Fas apoptotic inhibitory molecule 3 GFS:3673 |
| Gene name: | FAIM3 |
| Chromosome: | 1q32.1 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | TOSO |
| Name Aliases: | |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1916419 | Rat Genome Database ID: | RGD:1359282 |
| HGNC ID: | HGNC:14315 | RefSeq IDs: | NM_001142473 |
| Entrez Gene ID: | 9214 | Ensembl Gene ID: | ENSG00000162894 |
| VEGA IDs: | OTTHUMG00000036457 | UniProt ID: | O60667 |
| UCSC ID: | uc001hey.2 | OMIM ID: | 606015 |
| Pubmed: | PMID9586636 PMID 1563211 | ||
| CCDS IDs: | CCDSCCDS1473.1 CCDS CCDS44304.1 | ||
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010].
Function: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
Products for FAIM3 gene
| Catalog | Product Name | Application | Company |
| GFS:E03673 | Fas apoptotic inhibitory molecule 3; ELISA kit | ELISA | n/a |
| GFS:A03673 | Fas apoptotic inhibitory molecule 3; Anti | ANTIBODIES | n/a |
| GFS:P03673 | Fas apoptotic inhibitory molecule 3; Protien | Protien | n/a |
