Symbol: Name: ID: |
FAS Fas (TNF receptor superfamily, member 6) GFS:1732 |
Gene name: | FAS |
Chromosome: | 10q24.1 |
Previous Symbols: | FAS1, APT1, TNFRSF6 |
Previous Names: | tumor necrosis factor receptor superfamily, member 6 |
Aliases: | CD95, APO-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:95484 | Rat Genome Database ID: | RGD:619831 |
HGNC ID: | HGNC:11920 | RefSeq IDs: | NM_000043 |
Entrez Gene ID: | 355 | Ensembl Gene ID: | ENSG00000026103 |
VEGA IDs: | OTTHUMG00000018701 | UniProt ID: | P25445 |
UCSC ID: | uc001kfr.2 | OMIM ID: | 134637 |
Pubmed: | PMID1385299 PMID 1385309 | ||
CCDS IDs: | CCDSCCDS7393.1 CCDS CCDS7394.1 CCDS CCDS7395.1 |
The Fas receptor (FasR) is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq].
Products for FAS gene
Catalog | Product Name | Application | Company |
GFS:E01732 | Fas (TNF receptor superfamily, member 6); ELISA kit | ELISA | n/a |
GFS:A01732 | Fas (TNF receptor superfamily, member 6); Anti | ANTIBODIES | n/a |
GFS:P01732 | Fas (TNF receptor superfamily, member 6); Protien | Protien | n/a |