Symbol: Name: ID: |
ESX1 ESX homeobox 1 GFS:4152 |
Gene name: | ESX1 |
Chromosome: | Xq22.2 |
Previous Symbols: | ESX1L |
Previous Names: | extraembryonic, spermatogenesis, homeobox 1 homolog (mouse) |
Aliases: | ESXR1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:14865 | RefSeq IDs: | NM_153448 |
Entrez Gene ID: | 80712 | Ensembl Gene ID: | ENSG00000123576 |
VEGA IDs: | OTTHUMG00000022125 | UniProt ID: | Q8N693 |
UCSC ID: | uc004ely.2 | OMIM ID: | 300154 |
Pubmed: | PMID11374906 PMID 17242862 | ||
CCDS IDs: | CCDSCCDS14516.1 |
Homeobox protein ESX1 is a protein that in humans is encoded by the ESX1 gene.
This gene encodes a dual-function 65 kDa protein that undergoes proteolytic cleavage to produce a 45 kDa N-terminal fragment with a paired-like homeodomain and a 20 kDa C-terminal fragment with a proline-rich domain. The C-terminal fragment localizes to the cytoplasm while the N-terminal fragment localizes exclusively to the nucleus. In contrast to human, the mouse homolog has a novel PN/PF motif in the C-terminus and is paternally imprinted in placental tissue. This gene likely plays a role in placental development and spermatogenesis. [provided by RefSeq, Jan 2010].
Function: May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
Products for ESX1 gene
Catalog | Product Name | Application | Company |
GFS:E04152 | ESX homeobox 1; ELISA kit | ELISA | n/a |
GFS:A04152 | ESX homeobox 1; Anti | ANTIBODIES | n/a |
GFS:P04152 | ESX homeobox 1; Protien | Protien | n/a |