Symbol: Name: ID: |
ERO1LB ERO1-like beta (S. cerevisiae) GFS:3704 |
Gene name: | ERO1LB |
Chromosome: | 1q42.2-q43 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ERO1-L(beta) |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1914725 | Rat Genome Database ID: | RGD:1563548 |
HGNC ID: | HGNC:14355 | RefSeq IDs: | NM_019891 |
Entrez Gene ID: | 56605 | Ensembl Gene ID: | ENSG00000086619 |
VEGA IDs: | OTTHUMG00000039955 | UniProt ID: | Q86YB8 |
UCSC ID: | uc001hxt.2 | OMIM ID: | |
Pubmed: | PMID10818100 | ||
CCDS IDs: | CCDSCCDS31064.1 |
ERO1-like protein beta is a protein that in humans is encoded by the ERO1LB gene.
Function: Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.
Products for ERO1LB gene
Catalog | Product Name | Application | Company |
GFS:E03704 | ERO1-like beta (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A03704 | ERO1-like beta (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P03704 | ERO1-like beta (S. cerevisiae); Protien | Protien | n/a |