Symbol: Name: ID: |
ERRFI1 ERBB receptor feedback inhibitor 1 GFS:7071 |
Gene name: | ERRFI1 |
Chromosome: | 1p36.23 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MIG-6, GENE-33, RALT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921405 | Rat Genome Database ID: | RGD:1307599 |
HGNC ID: | HGNC:18185 | RefSeq IDs: | NM_018948 |
Entrez Gene ID: | 54206 | Ensembl Gene ID: | ENSG00000116285 |
VEGA IDs: | OTTHUMG00000001221 | UniProt ID: | Q9UJM3 |
UCSC ID: | uc001aoz.2 | OMIM ID: | 608069 |
Pubmed: | PMID10749885 PMID 2780291 PMID 12226756 PMID 11003669 | ||
CCDS IDs: | CCDSCCDS94.1 |
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.
ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development (By similarity).
Products for ERRFI1 gene
Catalog | Product Name | Application | Company |
GFS:E07071 | ERBB receptor feedback inhibitor 1; ELISA kit | ELISA | n/a |
GFS:A07071 | ERBB receptor feedback inhibitor 1; Anti | ANTIBODIES | n/a |
GFS:P07071 | ERBB receptor feedback inhibitor 1; Protien | Protien | n/a |