Symbol: Name: ID: |
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 GFS:4174 |
Gene name: | DNAJB6 |
Chromosome: | 7q36.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | MRJ |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344381 | Rat Genome Database ID: | RGD:1308207 |
HGNC ID: | HGNC:14888 | RefSeq IDs: | NM_005494 |
Entrez Gene ID: | 10049 | Ensembl Gene ID: | ENSG00000105993 |
VEGA IDs: | OTTHUMG00000157242 | UniProt ID: | O75190 |
UCSC ID: | uc003wnk.2 | OMIM ID: | 611332 |
Pubmed: | PMID10319584 PMID 9915854 | ||
CCDS IDs: | CCDSCCDS5946.1 CCDS CCDS47755.1 |
DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008].
Function: Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Reduces huntingtin aggregation associated with HD. Also reduces cellular toxicity and caspase-3 activity.
Products for DNAJB6 gene
Catalog | Product Name | Application | Company |
GFS:E04174 | DnaJ (Hsp40) homolog, subfamily B, member 6; ELISA kit | ELISA | n/a |
GFS:A04174 | DnaJ (Hsp40) homolog, subfamily B, member 6; Anti | ANTIBODIES | n/a |
GFS:P04174 | DnaJ (Hsp40) homolog, subfamily B, member 6; Protien | Protien | n/a |