| Symbol: Name: ID: |
DAB2IP DAB2 interacting protein GFS:6378 |
| Gene name: | DAB2IP |
| Chromosome: | 9q33.1-q33.3 |
| Previous Symbols: | |
| Previous Names: | |
| Aliases: | AF9Q34, DIP1/2, KIAA1743, AIP1 |
| Name Aliases: | nGAP-like protein, |
| Locus Type: | gene with protein product |
| Mouse Genome Database ID: | MGI:1916851 | Rat Genome Database ID: | RGD:621686 |
| HGNC ID: | HGNC:17294 | RefSeq IDs: | NM_032552 |
| Entrez Gene ID: | 153090 | Ensembl Gene ID: | ENSG00000136848 |
| VEGA IDs: | OTTHUMG00000020595 | UniProt ID: | Q5VWQ8 |
| UCSC ID: | uc004bln.2 | OMIM ID: | 609205 |
| Pubmed: | PMID11944990 PMID 11812785 | ||
| CCDS IDs: | CCDSCCDS6832.1 CCDS CCDS6833.2 | ||
Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene.
Products for DAB2IP gene
| Catalog | Product Name | Application | Company |
| GFS:E06378 | DAB2 interacting protein; ELISA kit | ELISA | n/a |
| GFS:A06378 | DAB2 interacting protein; Anti | ANTIBODIES | n/a |
| GFS:P06378 | DAB2 interacting protein; Protien | Protien | n/a |
