Symbol: Name: ID: |
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b GFS:4646 |
Gene name: | CBLB |
Chromosome: | 3q |
Previous Symbols: | |
Previous Names: | Cas-Br-M (murine) ectropic retroviral transforming sequence b |
Aliases: | RNF56 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2146430 | Rat Genome Database ID: | RGD:620535 |
HGNC ID: | HGNC:1542 | RefSeq IDs: | NM_170662 |
Entrez Gene ID: | 868 | Ensembl Gene ID: | ENSG00000114423 |
VEGA IDs: | OTTHUMG00000150654 | UniProt ID: | Q13191 |
UCSC ID: | uc003dwc.2 | OMIM ID: | 604491 |
Pubmed: | PMID7784085 | ||
CCDS IDs: | CCDSCCDS2948.1 |
E3 ubiquitin-protein ligase CBL-B is an enzyme that in humans is encoded by the CBLB gene.
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. May also be involved in EGFR ubiquitination and internalization.
Products for CBLB gene
Catalog | Product Name | Application | Company |
GFS:E04646 | Cas-Br-M (murine) ecotropic retroviral transforming sequence b; ELISA kit | ELISA | n/a |
GFS:A04646 | Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Anti | ANTIBODIES | n/a |
GFS:P04646 | Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Protien | Protien | n/a |