Symbol: Name: ID: |
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) GFS:7287 |
Gene name: | CHTF18 |
Chromosome: | 16p13.3 |
Previous Symbols: | C16orf41 |
Previous Names: | chromosome 16 open reading frame 41 |
Aliases: | CHL12, C321D2.4, Ctf18 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384887 | Rat Genome Database ID: | RGD:1310473 |
HGNC ID: | HGNC:18435 | RefSeq IDs: | NM_022092 |
Entrez Gene ID: | 63922 | Ensembl Gene ID: | ENSG00000127586 |
VEGA IDs: | OTTHUMG00000047838 | UniProt ID: | Q8WVB6 |
UCSC ID: | uc002cke.3 | OMIM ID: | 613201 |
Pubmed: | PMID12171929 | ||
CCDS IDs: | CCDSCCDS45371.1 |
Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.
CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009].
Function: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH.
Products for CHTF18 gene
Catalog | Product Name | Application | Company |
GFS:E07287 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A07287 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P07287 | CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae); Protien | Protien | n/a |