Symbol: Name: ID: |
CLP1 CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) GFS:6089 |
Gene name: | CLP1 |
Chromosome: | 11q12 |
Previous Symbols: | |
Previous Names: | |
Aliases: | HEAB, hClp1 |
Name Aliases: | ATP/GTPbinding protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2138968 | Rat Genome Database ID: | RGD:1307679 |
HGNC ID: | HGNC:16999 | RefSeq IDs: | NM_001142597 |
Entrez Gene ID: | 10978 | Ensembl Gene ID: | ENSG00000172409 |
VEGA IDs: | UniProt ID: | Q92989 | |
UCSC ID: | uc001nkw.2 | OMIM ID: | 608757 |
Pubmed: | PMID8896421 PMID 11060040 | ||
CCDS IDs: | CCDSCCDS7964.1 CCDS CCDS44600.1 |
Function: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.
Products for CLP1 gene
Catalog | Product Name | Application | Company |
GFS:E06089 | CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); ELISA kit | ELISA | n/a |
GFS:A06089 | CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); Anti | ANTIBODIES | n/a |
GFS:P06089 | CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae); Protien | Protien | n/a |