Symbol: Name: ID: |
CLK4 CDC-like kinase 4 GFS:3188 |
Gene name: | CLK4 |
Chromosome: | 5q35 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1098551 | Rat Genome Database ID: | |
HGNC ID: | HGNC:13659 | RefSeq IDs: | NM_020666 |
Entrez Gene ID: | 57396 | Ensembl Gene ID: | ENSG00000113240 |
VEGA IDs: | OTTHUMG00000130893 | UniProt ID: | Q9HAZ1 |
UCSC ID: | uc003mjf.1 | OMIM ID: | 607969 |
Pubmed: | PMID11170754 | ||
CCDS IDs: | CCDSCCDS4437.1 |
The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008].
Function: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines. Required for the regulation of alternative splicing of MAPT/TAU.
Products for CLK4 gene
Catalog | Product Name | Application | Company |
GFS:E03188 | CDC-like kinase 4; ELISA kit | ELISA | n/a |
GFS:A03188 | CDC-like kinase 4; Anti | ANTIBODIES | n/a |
GFS:P03188 | CDC-like kinase 4; Protien | Protien | n/a |