Symbol: Name: ID: |
CEBPB CCAAT/enhancer binding protein (C/EBP), beta GFS:7210 |
Gene name: | CEBPB |
Chromosome: | 20q13.1 |
Previous Symbols: | TCF5 |
Previous Names: | |
Aliases: | LAP, CRP2, NFIL6, IL6DBP, C/EBP-beta |
Name Aliases: | liver-enriched transcriptional activator protein, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:88373 | Rat Genome Database ID: | RGD:2327 |
HGNC ID: | HGNC:1834 | RefSeq IDs: | NM_005194 |
Entrez Gene ID: | 1051 | Ensembl Gene ID: | ENSG00000172216 |
VEGA IDs: | OTTHUMG00000032715 | UniProt ID: | P17676 |
UCSC ID: | uc002xvi.1 | OMIM ID: | 189965 |
Pubmed: | PMID1535333 PMID 1840554 | ||
CCDS IDs: | CCDSCCDS13429.1 |
CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I gene. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity).
Products for CEBPB gene
Catalog | Product Name | Application | Company |
GFS:E07210 | CCAAT/enhancer binding protein (C/EBP), beta; ELISA kit | ELISA | n/a |
GFS:A07210 | CCAAT/enhancer binding protein (C/EBP), beta; Anti | ANTIBODIES | n/a |
GFS:P07210 | CCAAT/enhancer binding protein (C/EBP), beta; Protien | Protien | n/a |