Symbol: Name: ID: |
BRAP BRCA1 associated protein GFS:897 |
Gene name: | BRAP |
Chromosome: | 12q24 |
Previous Symbols: | |
Previous Names: | |
Aliases: | BRAP2, RNF52, IMP |
Name Aliases: | impedes mitogenic signal propagation, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919649 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1099 | RefSeq IDs: | NM_006768 |
Entrez Gene ID: | 8315 | Ensembl Gene ID: | ENSG00000089234 |
VEGA IDs: | UniProt ID: | Q7Z569 | |
UCSC ID: | uc001tsn.3 | OMIM ID: | 604986 |
Pubmed: | PMID9497340 PMID 19198608 | ||
CCDS IDs: | CCDSCCDS9154.1 |
The protein encoded by BRAP was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
Products for BRAP gene
Catalog | Product Name | Application | Company |
GFS:E00897 | BRCA1 associated protein; ELISA kit | ELISA | n/a |
GFS:A00897 | BRCA1 associated protein; Anti | ANTIBODIES | n/a |
GFS:P00897 | BRCA1 associated protein; Protien | Protien | n/a |