Symbol: Name: ID: |
BMX BMX non-receptor tyrosine kinase GFS:709 |
Gene name: | BMX |
Chromosome: | Xp22.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | ETK, PSCTK3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1101778 | Rat Genome Database ID: | RGD:1565643 |
HGNC ID: | HGNC:1079 | RefSeq IDs: | NM_001721 |
Entrez Gene ID: | 660 | Ensembl Gene ID: | ENSG00000102010 |
VEGA IDs: | OTTHUMG00000021180 | UniProt ID: | P51813 |
UCSC ID: | uc004cwx.3 | OMIM ID: | 300101 |
Pubmed: | PMID7970727 | ||
CCDS IDs: | CCDSCCDS14168.1 |
Cytoplasmic tyrosine-protein kinase BMX is an enzyme that in humans is encoded by the BMX gene. This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Activity is required for interleukin 6 (IL-6) induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells
Products for BMX gene
Catalog | Product Name | Application | Company |
GFS:E00709 | BMX non-receptor tyrosine kinase; ELISA kit | ELISA | n/a |
GFS:A00709 | BMX non-receptor tyrosine kinase; Anti | ANTIBODIES | n/a |
GFS:P00709 | BMX non-receptor tyrosine kinase; Protien | Protien | n/a |