Symbol: Name: ID: |
BID BH3 interacting domain death agonist GFS:445 |
Gene name: | BID |
Chromosome: | 22q11.2 |
Previous Symbols: | |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:108093 | Rat Genome Database ID: | RGD:620160 |
HGNC ID: | HGNC:1050 | RefSeq IDs: | NM_001196 |
Entrez Gene ID: | 637 | Ensembl Gene ID: | ENSG00000015475 |
VEGA IDs: | OTTHUMG00000150087 | UniProt ID: | P55957 |
UCSC ID: | uc002znc.1 | OMIM ID: | 601997 |
Pubmed: | PMID8918887 PMID 9721221 | ||
CCDS IDs: | CCDSCCDS13747.1 CCDS CCDS13748.1 CCDS CCDS13749.1 |
BH3 interacting domain death agonist encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq].
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2
Products for BID gene
Catalog | Product Name | Application | Company |
GFS:E00445 | BH3 interacting domain death agonist; ELISA kit | ELISA | n/a |
GFS:A00445 | BH3 interacting domain death agonist; Anti | ANTIBODIES | n/a |
GFS:P00445 | BH3 interacting domain death agonist; Protien | Protien | n/a |