Symbol: Name: ID: |
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 GFS:6012 |
Gene name: | ARAP1 |
Chromosome: | 11q13.3 |
Previous Symbols: | CENTD2 |
Previous Names: | centaurin, delta 2 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916960 | Rat Genome Database ID: | RGD:1310385 |
HGNC ID: | HGNC:16925 | RefSeq IDs: | NM_001040118 |
Entrez Gene ID: | 116985 | Ensembl Gene ID: | ENSG00000186635 |
VEGA IDs: | OTTHUMG00000157102 | UniProt ID: | Q96P48 |
UCSC ID: | uc001osu.2 | OMIM ID: | 606646 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8217.2 CCDS CCDS41687.1 CCDS CCDS44671.1 |
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
Function: Phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity).
Products for ARAP1 gene
Catalog | Product Name | Application | Company |
GFS:E06012 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; ELISA kit | ELISA | n/a |
GFS:A06012 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; Anti | ANTIBODIES | n/a |
GFS:P06012 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1; Protien | Protien | n/a |