Symbol: Name: ID: |
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 GFS:6008 |
Gene name: | AGAP2 |
Chromosome: | 12q13.2 |
Previous Symbols: | CENTG1 |
Previous Names: | centaurin, gamma 1 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3580016 | Rat Genome Database ID: | RGD:628844 |
HGNC ID: | HGNC:16921 | RefSeq IDs: | NM_001122772 |
Entrez Gene ID: | 116986 | Ensembl Gene ID: | ENSG00000135439 |
VEGA IDs: | UniProt ID: | Q99490 | |
UCSC ID: | uc001spq.2 | OMIM ID: | 605476 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS8951.1 CCDS CCDS44932.1 |
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is an enzyme that in humans is encoded by the AGAP2 gene.
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
Function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Products for AGAP2 gene
Catalog | Product Name | Application | Company |
GFS:E06008 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; ELISA kit | ELISA | n/a |
GFS:A06008 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; Anti | ANTIBODIES | n/a |
GFS:P06008 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; Protien | Protien | n/a |