Symbol: Name: ID: |
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide GFS:3497 |
Gene name: | ATP1A4 |
Chromosome: | 1q21-q23 |
Previous Symbols: | ATP1AL2 |
Previous Names: | ATPase, Na+/K+ transporting, alpha polypeptide-like 2 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1351335 | Rat Genome Database ID: | RGD:61952 |
HGNC ID: | HGNC:14073 | RefSeq IDs: | NM_001001734 |
Entrez Gene ID: | 480 | Ensembl Gene ID: | ENSG00000132681 |
VEGA IDs: | OTTHUMG00000031609 | UniProt ID: | Q13733 |
UCSC ID: | uc001fve.3 | OMIM ID: | 607321 |
Pubmed: | PMID1981991 PMID 3035563 | ||
CCDS IDs: | CCDSCCDS1197.1 CCDS CCDS44255.1 |
Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 4 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Function: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Plays a role in sperm motility.
Products for ATP1A4 gene
Catalog | Product Name | Application | Company |
GFS:E03497 | ATPase, Na+/K+ transporting, alpha 4 polypeptide; ELISA kit | ELISA | n/a |
GFS:A03497 | ATPase, Na+/K+ transporting, alpha 4 polypeptide; Anti | ANTIBODIES | n/a |
GFS:P03497 | ATPase, Na+/K+ transporting, alpha 4 polypeptide; Protien | Protien | n/a |