Symbol: Name: ID: |
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 GFS:3231 |
Gene name: | ATP6V0D1 |
Chromosome: | 16q22 |
Previous Symbols: | ATP6D |
Previous Names: | ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D, "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" |
Aliases: | ATP6DV, VATX, VPATPD, P39, Vma6 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1201778 | Rat Genome Database ID: | RGD:1306159 |
HGNC ID: | HGNC:13724 | RefSeq IDs: | NM_004691 |
Entrez Gene ID: | 9114 | Ensembl Gene ID: | ENSG00000159720 |
VEGA IDs: | OTTHUMG00000137515 | UniProt ID: | P61421 |
UCSC ID: | uc002ete.1 | OMIM ID: | 607028 |
Pubmed: | PMID8250920 | ||
CCDS IDs: | CCDSCCDS10838.1 |
V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).
Products for ATP6V0D1 gene
Catalog | Product Name | Application | Company |
GFS:E03231 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; ELISA kit | ELISA | n/a |
GFS:A03231 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Anti | ANTIBODIES | n/a |
GFS:P03231 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1; Protien | Protien | n/a |