Symbol: Name: ID: |
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 GFS:7178 |
Gene name: | ATP6AP2 |
Chromosome: | Xp11.4 |
Previous Symbols: | ATP6IP2 |
Previous Names: | ATPase, H+ transporting, lysosomal interacting protein 2 |
Aliases: | M8-9, APT6M8-9, ATP6M8-9 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1917745 | Rat Genome Database ID: | RGD:1561269 |
HGNC ID: | HGNC:18305 | RefSeq IDs: | NM_005765 |
Entrez Gene ID: | 10159 | Ensembl Gene ID: | ENSG00000182220 |
VEGA IDs: | OTTHUMG00000024103 | UniProt ID: | O75787 |
UCSC ID: | uc004det.2 | OMIM ID: | 300556 |
Pubmed: | PMID9556572 PMID 11590366 | ||
CCDS IDs: | CCDSCCDS14252.1 |
The renin receptor also known as ATPase H(+)-transporting lysosomal accessory protein 2, or the prorenin receptor, is a protein that in humans is encoded by the ATP6AP2 gene.
This gene encodes a protein that is associated with adenosine triphosphatases (ATPases). Proton-translocating ATPases have fundamental roles in energy conservation, secondary active transport, acidification of intracellular compartments, and cellular pH homeostasis. There are three classes of ATPases- F, P, and V. The vacuolar (V-type) ATPases have a transmembrane proton-conducting sector and an extramembrane catalytic sector. The encoded protein has been found associated with the transmembrane sector of the V-type ATPases. [provided by RefSeq, Jul 2008].
Function: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).
Products for ATP6AP2 gene
Catalog | Product Name | Application | Company |
GFS:E07178 | ATPase, H+ transporting, lysosomal accessory protein 2; ELISA kit | ELISA | n/a |
GFS:A07178 | ATPase, H+ transporting, lysosomal accessory protein 2; Anti | ANTIBODIES | n/a |
GFS:P07178 | ATPase, H+ transporting, lysosomal accessory protein 2; Protien | Protien | n/a |